By Errol C Friedberg
With a Foreword through Sydney Brenner (Nobel laureate in body structure or medication, 2002)
This biography information the lifetime of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's lifestyles from start, in 1926, to the current, with specified emphasis on his huge, immense medical contributions, together with being the 1st to advance know-how that ended in gene cloning technological know-how. In 1980, Berg got a Nobel Prize in chemistry for this work.
In addition to his contributions within the examine laboratory, Berg orchestrated and oversaw a historical assembly at Asilomar, California that based on a threatening controversy surrounding the belief via many of the damaging power of recombinant DNA expertise. This assembly did a lot to prevent this controversy and to install position the rules of recombinant DNA paintings, hence placing fears to rest.
The recombinant DNA controversy was once a historical consequence of the invention of gene cloning. significantly, it represented a paramount instance of medical foresight and due diligence via the clinical group, instead of by way of regulatory entities within the usa and lots of different nations. the final word attractiveness of gene/DNA cloning ended in a brand new period of contemporary biology that flourishes to the present.
This ebook is aimed basically at scientists and people in education. The booklet strives to easily offer info for the final reader, yet isn't really in particular adapted for a common examining audience.
While many books hide the recombinant DNA controversy, none have satisfactorily addressed this old interval and are frequently contradictory in regards to the many who is, where's, and why's concerned. also, the nice majority of those have been written by means of non-scientists. This biography of Paul Berg offers entry to various archived letters and records at Stanford college now not formerly addressed, and to the chronology of occasions as recalled and documented by means of him, in addition to different key personalities, lots of whom have been interviewed.
- Part I:
- Growing Up in Brooklyn
- The crucial Paul Berg
- College — and global warfare II
- Western Reserve University
- Part II:
- Washington college, St. Louis
- Discovering move RNA
- Stanford collage — and Its Refurbished division of Biochemistry
- Transcription and Translation: New Directions
- Part III:
- Making Recombinant DNA — the 1st Faltering Steps
- Making Recombinant DNA — a tremendous Breakthrough
- EcoRI limit Endonuclease — a tremendous Breakthrough
- “Coincidence is the be aware We Use once we cannot See the Levers and Pulleys”
- Yet one other Stanford Contribution
- Part IV:
- An ancient assembly in Hawaii
- The Recombinant DNA Controversy
- A Momentous Gordon examine Conference
- Making Recombinant Molecules with Frog DNA
- The Controversy Heats Up
- Asilomar II
- The Dissenters: a special aspect of View
- The Aftermath
- Legislative and Revisionist demanding situations to Recombinant DNA
- Asilomar II — classes Learned
- Part V:
- The Nobel Prize in Chemistry
- Commercializing the Technology
- Life is going on
- The “Retirement” Years
- Public coverage concerns — and different Interests
- Personal Challenges
Readership: Researchers, graduate scholars, undergraduates in lifestyles sciences, drugs and chemistry and lay public.
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A Biography of Paul Berg:The Recombinant DNA Controversy Revisited by Errol C Friedberg